The presumptive role of Nurr1 in PD pathogenesis made us also to explore the possible effect of the mutation S125C that has been shown to be present in a PD patient [25] in Nurr1 degradation and consistently with the results presented here, the missense mutation that is located further downstream of the core N-terminal (aa1–31) did not affect the degradation rate of Nurr1 (data not shown), while this mutant has been reported to have a markedly reduced transactivation-activity [34]. This evidence concerns the gene NR4A2 and Parkinson disease.