On the other hand, DNA microarray data from CML [46] suggest that, in addition to PRAME, other factors must be necessary for down-regulation of TRAIL because not all CML samples express high amount of PRAME and in-between the CML samples there is no clear correlation between PRAME and TRAIL. Here, TNFSF10 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.