The imprinted genes studied were: GRB10 ICR, IGF2 DMR0 and IGF2 DMR2, which are implicated in the insulin-like growth factor signaling pathway that is often deregulated in breast cancer [10], [11]; H19 ICR, which is a potential tumor suppressor gene [12]; KvDMR[13] and SNRPN/SNURF ICR[14], which are known to be altered in different human cancers. The gene discussed is GRB10; the disease is cancer.