AR and prostate cancer: Data presented in this article are collected from the study of established AR-positive, androgen-dependent and lower AR expression human prostate cancer cells (LNCaP/LNCaP-s), additional study may be warranted to define the links with the host microenvironment, for example, cancer-associated fibroblast cell interaction which was proposed by Sotgia F in his “two-compartment tumor metabolism” model, these catabolic host cells could fuel anabolic cancer cell growth and metastasis via mitochondrial metabolism.