In addition, we evaluated the relationship of serum progranulin and CTRP3 levels with various cardiometabolic risk factors, such as insulin resistance, high sensitivity C-reactive protein (hsCRP), IL-6, estimated glomerular filtration rate (eGFR), and adiponectin levels, as well as CIMT, which is a reliable indicator of early carotid atherosclerosis. This evidence concerns the gene IL6 and Insulin resistance.