However, given the low frequency of this variant (0.0011 in cases and 0.00077 in controls), its variable prevalence in the available populations (0.6% in the Italian, 0.3% in the Spanish, but not found in the Netherland samples and found once (0.14%) in the Australian controls, data not shown) and FANCM’s important role in DNA repair, it would be interesting to analyze this gene in a higher number of samples to fully understand its contribution to BC. This evidence concerns the gene FANCM and breast cancer.