So, our results from xenograft models further confirmed that combination of photofrin based PDT and miR-99a transfection inhibited FGFR3 and PI3K/Akt signaling pathways to promote p53-mediated mitochondrial caspase-dependent apoptosis in human glioblastomas in vivo. The gene discussed is FGFR3; the disease is glioblastoma.