FBN3 and polycystic ovary syndrome: In that study it was concluded that ‘since fibrillins are stromal matrices and since the ovarian stromal compartments are altered in women with PCOS, fibrillin 3 expression in the developing fetal ovary, via the activity of TGFβ to regulate stroma formation and function, could predispose an individual to PCOS in later life’ [2].