After correcting for multiple comparisons, a significant association with SPARE-AD was found for apolipoprotein E (ApoE protein, q<0.0001), brain natriuretic peptide (BNP, q = 0.0007), chromogranin A (CgA, q = 0.033), cortisol (q = 0.033), eotaxin 3(ET-3, q = 0.001), insulin-like growth factor binding protein 2 (IGFBP-2, q = 0.022) and macrophage inflammatory protein1 alpha (MIP-1α, q = 0.031). The gene discussed is EDN3; the disease is Alzheimer disease.