MAP3K4 and retinoblastoma: For instance, the following appeared among the 30 top-ranking genes: DDX1, which is involved in cellular growth and division and previously described as implicated in tumors including neuroblastoma, Wilms tumor, retinoblastoma, testicular carcinoma, and breast cancer [6]; EIF4G1, whose encoded protein enhances the synthesis of mRNA and was described as affecting the tumorigenic potential in a breast cancer cell line [7]; ENO1, which binds to the MYC promoter as a transcriptional repressor, thus likely acting as a tumor suppressor [8]; and MAP3K4, a kinase of CSBP2 and JNK pathways [9].