The combination of the two current experiments (Fig. 1) with the data from our recently published CLP-Only study [25] allowed us to: 1) follow concentration of PAI-1 in the blood over the seven-day period (from the TH onset), 2) provide a comprehensive outcome-dependent characterization of early and delayed fluctuations of PAI-1 as mice transitioned from the trauma/hemorrhage to post-traumatic sepsis, and finally 3) establish the modulatory importance of the TH hit in post-traumatic CLP sepsis. Here, SERPINE1 is linked to Sepsis.