SERPINE1 and serum lipopolysaccharide activity: Increased fibrinolytic activity was reflected by a significant increase in FDP levels in both P. aeruginosa pneumonia (rtPA p<0.05 versus saline; and anti–rat PAI1 p<0.05 versus saline) and endotoxemia–induced lung injury (rtPA p<0.05 versus saline; and anti–rat PAI1 p<0.05 versus saline).