Specific biochemical indicators for bone turnover, including bone formation markers (B-ALP; Osteocalcin et al), and bone resorption markers (NTx; Tartrate-resistant acid phosphatase-5b, TRCAP-5b; and Carboxy-terminal collagen crosslinks, CTX etc), might be used as index for disease progression of osteoporosis[4]–[6]. Here, ACP5 is linked to osteoporosis.