Regarding mechanisms likely therein involved, locally produced SPARC was found to stimulate collagen deposition, inflammatory cells recruitment, TGF-β1 production, mesenchymal cell proliferation and ECM proteins synthesis, in the context of kidney, skin and/or lung fibrogenesis [3], [4], while no studies were performed on liver fibrosis models. Here, TGFB1 is linked to Hepatic fibrosis.