Surprisingly, hematoma volumes were not different between saline controls (mean±SD 7.5±3.4 μl) and tPA-treated mice (7.6±3.5 μl), but heparin significantly worsened hemorrhage (19.8±8.8 μl, one-way ANOVA between group differences p<0.001, post-hoc saline vs. tPA p = 1.000, saline vs. heparin p<0.001, tPA vs. heparin p<0.001, Fig. 2B). The gene discussed is PLAT; the disease is hematoma.