XIAP and rhabdomyosarcoma: In addition to demonstrating that blocking activation of NF-κΒ by curcumin resulted in IR-mediated induction of NF-κΒ-responsive genes involved in cell proliferation (cyclin D1) and survival (XIAP and bcl-2), we showed that the combination of curcumin and IR caused a profound decrease in microvessel density in rhabdomyosarcoma xenografts.