While the development defects in germline Ssb1 knockout mice were surprising, effects of inducible ablation of Ssb1 in adult mice revealed phenotypes more relevant to the proposed role of Ssb1 in maintaining genomic stability, as we observed defects in spermatogenesis, increased radiation sensitivity, increased genomic instability as well as an increased tumour incidence in induced Ssb1−/− mice. The gene discussed is NABP2; the disease is neoplasm.