Most of the 16 novel loci implicated in the regulation of TSH are highly represented in the thyroid with the exception of PRDM11, expressed in brain, ABO, in blood, and MIR1179. PDE10A encodes a cAMP-stimulated phosphodiesterase, which was previously only suggestively associated with TSH levels and hypothyroidism [13], [34], although the tested variants were weakly correlated with our top signal (r2 = 0.55 with rs2983521 and r2 = 0.15 with rs9347083). Here, PDE10A is linked to hypothyroidism.