Several detected loci have potential clinical relevance and have been previously implicated both in Mendelian endocrine disorders (LHX3 [MIMM#221750], FOXE1 [MIMM#241850], PDE8B [MIMM#614190], NR3C2 [MIMM#177735], INSR [MIMM#609968], GLIS3 [MIMM#610199]) and thyroid cancer (FOXE1[19], VEGFA[53], IGFBP5[54], INSR[55], NGR1[32], MBIP[32], FGF7[56]). This evidence concerns the gene PDE8B and endocrine system disorder.