FOXE1 and hypothyroidism: The most associated SNP at the FOXE1 locus, rs7045138, is a surrogate for rs1443434(r2 = 0.97), previously only suggestively associated with FT4 levels [18], and is also correlated with SNPs recently reported to be associated with both low serum TSH and FT4 levels (r2 = 0.59 with rs965513) [19], as well as with hypothyroidism (r2 = 0.59 with rs7850258) [20].