TGFB1 and neoplasm: These findings reveal considerable alteration in the cellular and molecular properties of the tumor microenvironment in Tgfbr2fspKO compared to Tgfbr2flox/flox mice, suggesting that multiple inflammatory mediators interacting with an altered microenvironment are implicated in the progression of SCC following deletion of TGF-β signaling in stromal fibroblasts.