EGFR and central nervous system cancer: The neurotransmitter glutamate, which mediates synaptic transmission through the N-methyl-D-aspartate glutamate receptors 2A and 2B (GRIN2A and GRIN2B) that appear in the PCST network, can promote glioma cell growth [50], and this pro-proliferative effect in U87MG cells is due to EGFR signaling [51].