Serum Ang-2 levels and Ang-2/Ang-1 ratio were observed to be significantly higher in patients with HF than in patients without HF (2,203.1±122.0 vs. 2,102.3±114.4 pg/ml, P=0.001 and 11.4±1.6×10−2 vs. 10.6±1.1×10−2, P=0.007). This evidence concerns the gene ANGPT2 and hydrops fetalis.