In the multivariable logistic regression analysis, Ang-2 (P=0.031), Ang-2/Ang-1 (P=0.018) and NT-proBNP (P=0.001) were independently associated with HF, following adjustment for age, gender, hypertension, diabetes mellitus, time from symptom onset to reperfusion, LVEF, serum creatinine, hemoglobin (Hb) level and peak cTnT (Table II). The gene discussed is ANGPT2; the disease is diabetes mellitus.