EGFR and schizophrenia: Animal studies demonstrate that acute and subchronic brain activation of ErbB1 triggers dopamine release in the striatum or globus pallidus, leading to behavioral impairments relevant to schizophrenia (Futamura et al., 2003; Tohmi et al., 2005; Mizuno et al., 2008; Sotoyama et al., 2011).