In the current study, we focused on the roles of MMP-7 and TIMP-2 in the tissue of 98 CCRCC patients in relation to the clinicopathological characteristics of tumors, including pathological grade and clinical stage, and the survival rate of the patients, using tissue microarray, immunohistochemistry and RT-PCR. Here, TIMP2 is linked to nonpapillary renal cell carcinoma.