In the present study, we focused on the role of MMP-7 associated with TIMP-2 in human CCRCC tissues to determine the correlation with clinicopathological features and survival rate using tissue microarray, immunohistochemistry and RT-PCR to evaluate the clinical value of MMP-7 and TIMP-2 proteins in CCRCC. Here, TIMP2 is linked to nonpapillary renal cell carcinoma.