In order to fully understand the biological importance of LASS2, we examined the mRNA and protein expression of LASS2 in human bladder cancer cell lines (BIU-87, T24, EJ and EJ-M3) with diverse proliferation and invasion potential, and analyzed the potential role of the tumor metastasis supressor gene LASS2 in these human bladder cancer cell lines. The gene discussed is CERS2; the disease is urinary bladder carcinoma.