Voors et al(12) completed a 2-year follow-up of 224 patients and identified that copeptin was an effective prognostic indicator of heart failure following acute myocardial infarction (AMI); it was found to be more effective than the currently accepted indicators, B-type natriuretic peptide (BNP) and amino-terminal B-type natriuretic peptide (NT-proBNP). This evidence concerns the gene NPPB and heart failure.