Severe CNS types of anomalies were found in 63.22% of IP patients with CNS anomalies without genetically confirmed IP and in 54.00% of IP patients with CNS types of anomalies that were positively genetically tested for the IKBKG mutation, but the difference was not significant (χ2=1.35; df=1; p=0.24>0.05). The gene discussed is IKBKG; the disease is incontinentia pigmenti.