Because history of organic hypothalamic-pituitary disorder had 100% PPV for persistent GHD during transition, results for predictive value of IGF-I SDS, IGFBP-3 SDS, age at original diagnosis, body weight, and BMI are presented below only for the 55 patients with history of IGHD. This evidence concerns the gene IGFBP3 and isolated congenital growth hormone deficiency.