ESR1 and neoplasm: Finally, we also found that biclusters show stronger prognostic association with disease recurrence within pathology-specific tumour subsets (Additional file 3: Table S5 (b)-(e): LN- patient subgroup, univariate Cox PH p = 0.000183; ER+ patient subgroup, p = 0.00406; Grade 2 tumour subgroup, p = 0.000171; Grade 3 tumour subgroup, p = 0.0153).