Whereas the transfer of wildtype (WT) naive CD4+ T cells into Rag−/− hosts results in intestinal inflammation and wasting, the transfer of RORγ−/− or IL-23R−/− T cells, or the use of IL-23p19−/− recipient mice, results in highly attenuated intestinal disease 60, 86, 87. The gene discussed is CD4; the disease is intestinal disorder.