Indeed, an initial report suggested that T cell intrinsic NOD2 was important for CD4 T cell-dependent IFNγ responses to control Toxiplasma gondii in mice as well as for induction of colitis in an adoptive transfer model in which WT or NOD2−/− CD4 T cells were transferred into RAG−/− mice [7]. The gene discussed is CD4; the disease is colitis.