From analysis of the mRNA profile, we also predict that the important tumor suppressor CDKN2A is a target of miR-125b and miR-374a has been related to survival in lung cancer [33]; in Table S4 we report several anti-correlated, predicted targets that could explain its ‘protective’ action: ATM, GADD45A, CCND1 have key DNA damage response roles; Ets2, Met, Fos are fundamental proteins in cancer signaling so their down-regulation by over-expression of miR-374a is supportive of its ‘protective’ capacity. This evidence concerns the gene CDKN2A and cancer.