13 miRNAs (Fig. 1A) differentially expressed in the normal vs tumor comparison, represent a strictly tumor-specific pool for which IPA ingenuity software identified observed targets and signal pathways involved; examples are Integrin, protein kinase A, Thrombin, Phospholipase C, FAK, RhoA, ILK, and CAMP signaling, proliferation/apoptosis related and thus expressed in the tumor microenvironment [29]. Here, RHOA is linked to neoplasm.