Leukemia-associated RhoGEF (LARG), originally isolated from a patient with acute myeloid leukemia [6], is one of the key GEFs mediating RhoA activation and belongs to the regulator of G protein signaling (RGS) domain-containing GEFs, together with p115RhoGEF and PDZ-RhoGEF [7]. This evidence concerns the gene ARHGEF12 and acute myeloid leukemia.