BIRC5 and neoplasm: Figure 6 shows a typical results from two patients with or without the detergent-soluble cytoplasmic Survivin in primary cancerous tissues (case A is a patient without metastasis and case B is a patient with metastasis). Clinicopathological significance of the detergent-soluble cytoplasmic Survivin expression was determined for the forty cases. The positive cases were significantly increased in tumor size (<0.005), primary colorectal cancer with lymph node metastasis (<0.001), and primary colorectal cancer with distant metastasis (<0.01), compared with the negative cases (Table 1).