H2AX and cancer: It should be noted that several genes identified are known to have functions that might be relevant to cancer development: BAZ1B regulates the DNA-damage response by phosphorylating the histone H2A.X; POLN is a DNA polymerase that performs translesion synthesis in response to DNA damage; and FBOX11, a component of the Skp1-Cullin1-F-box (SCF) complex, promotes neddylation of p53 and inhibits its transcriptional activity.