Notably, mutations in minichromosome maintenance-deficient 4 (MCM4) which forms part of a protein complex which is essential for DNA replication and genome stability are associated with a variant of FGD found in the Irish Traveller population where adrenal failure is accompanied by short stature, chromosome instability, and natural killer cell dysfunction (O’Riordan et al., 2008; Gineau et al., 2012; Hughes et al., 2012). The gene discussed is MCM4; the disease is Aarskog-Scott syndrome, X-linked.