MRAP expression is necessary and sufficient for the functional expression of MC2R constructs in heterologous cell lines such as chinese hamster ovary (CHO) cells and SK-N-SH cells which are derived from ovarian and neuroblastoma tissue, respectively and do not endogenously express measurable levels of MRAP (Metherell et al., 2005; Sebag and Hinkle, 2007). This evidence concerns the gene MRAP and neuroblastoma.