DUOX2 and malignant colon neoplasm: These results are consistent with the observation that the expression of Duox2 is upregulated 10-fold in pre-malignant adenomatous polyps of the colon compared to adjacent colonic mucosa as determined by expression array analysis (16), as well as our finding that Duox2 expression at the mRNA level is dramatically increased in some surgically-resected colon cancers (7).