These results reinforce the previous immunoblots (Fig. 2) demonstrating that IFN-γ enhances Duox2 expression in crude cell extracts from BxPC-3 pancreatic cancer cells; in those experiments, IFN-γ upregulated the mRNA expression of Duox2, but not Duox1 or any other member of the NADPH oxidase gene family (data not shown). The gene discussed is DUOX2; the disease is familial pancreatic carcinoma.