DUOX1 and neoplasm: Furthermore, in light of recent studies demonstrating that either inhibition of Nox-related oxidant stress or other anti-inflammatory interventions can significantly diminish the late effects of gastrointestinal inflammation (24,25), our demonstration of increased Duox expression in gastrointestinal cancer suggests that pharmacologic inhibition of Nox expression might be a novel therapeutic intervention capable of interdicting the development of oxidant-mediated neoplasia.