DUOXA2 and familial pancreatic carcinoma: More importantly, we found that in the MIA PaCa-2 human pancreatic cancer cell line, which is not responsive to IFN-γ and does not constitutively express Duox2, overexpression of Duox2 and its cognate maturation factor, DuoxA2, produced a functionally active Duox2 protein that could be quantitated with the Duox S-12 antibody (Fig. 3B).