Based on the knowledge that the immune system, for example, the cytotoxic CD8+ T cells, can be specifically directed against TAAs, different vaccines consisting of professional antigen-presenting cells [i.e., dendritic cells (DCs)] loaded with either allogeneic or autologous tumor-derived lysates or RNA with or without alongside administration of IL-2 were tested [24, 25]. Here, CD8A is linked to neoplasm.