In addition it has been shown that GRP78 induces chemoresistance development in brain endothelial cells, favoring therefore tumor vascularization and metastatic spread (Virrey et al., 2008) and that GRP78 inhibition re-sensitize acute lymphoblastic leukemia cells refractory to vincristine (Uckun et al., 2011). The gene discussed is HSPA5; the disease is acute lymphoblastic leukemia.