MMP14 and type 1 diabetes mellitus: The inhibition of MT1-MMP proteolysis of CD44 drastically reduced the diabetogenic efficiency of T cells, immobilized T cells on the endothelium, repressed the homing of diabetogenic T cells into the pancreatic islets, reduced insulitis and mononuclear cell infiltration and promoted the recovery of the insulin-producing β cells in non-obese diabetic (NOD) mice with freshly developed T1D.