ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Some of these have been tested, with encouraging results, for actual novelty in a very preliminary way by internet searches (e.g., “xyz obesity” in Google or PubMed) where “xyz” is one of the candidates and “actual novelty” is defined as low hit rates, near or at zero, compared to known biomarkers (e.g., “adiponectin obesity”) with hit rates in the hundreds of thousands.