In an NRI analysis, the same model combining NGAL (T0) with the ED physician's clinical judgement was compared to a model combining admission sCr (T0) results with the ED physician's clinical judgement and the NRI (95% CI) was 32.4 percentage points (3.02 to 61.8), meaning that the percentage correct in the classification of AKI improved significantly by 32.4 points. The gene discussed is LCN2; the disease is acute kidney injury.