As shown in Table 1, Mart-126L- and/or GP100154/209/280-specific CD8+ T cells could be detected to similar levels in fresh (i.e. unexpanded) and IL-2, IL-15 and IL-21 aAPC expanded TIL samples, indicating that tumor antigen specificity was maintained after aAPC-mediated expansion. This evidence concerns the gene IL21 and neoplasm.