INS and type 2 diabetes mellitus: As shown in Figure 1, type 2 diabetes mellitus is associated with insulin resistance, inflammation with increased inflammatory markers such as Interleukin 6 and increased reactive oxygen species with all of which being related to high insulin level, which in turn activates the insulin receptor, which is a tyrosine kinase receptor, expressed in skeletal muscle, adipose tissue, liver, and other tissues including normal breast tissue.