CD47 has also been shown to be involved in the regulation of intracellular Ca2+ ([Ca2+]i), exemplified by its regulation of an integrin-dependent increase in [Ca2+]i in endothelial cells [31] and tumor cells [32], and that CD47 synergizes with T cell receptor-stimulated elevations of [Ca2+]i in T lymphocytes [33, 34]. This evidence concerns the gene CD47 and neoplasm.