AFP and Cirrhosis: SELDI-TOF analysis of sera from 120 patients affected by HCC and 120 affected by cirrhosis showed five proteomic peaks (m/z 3324, 3994, 4665, 4795, and 5152) able to achieve, especially for early stage HCC, a diagnostic value better than serum AFP (83% sensitivity and 92% specificity in the test set) [100].