In a group of sera (54 SCLC, 24 NSCLC, 32 pneumonia patients, and 40 healthy subjects), SELDI-TOF spectra data analyzed by support vector machine (SVM) gave three patterns able to distinguish SCLC from pneumonia, NSCLC patients and from healthy individuals better than neuron specific enolase (NSE). This evidence concerns the gene ENO2 and small cell lung carcinoma.