Three proteins/protein fragments, described as acute-phase reactants (apolipoprotein A1, m/z 28043, a truncated form of transthyretin, m/z 12828, and a fragment of inter-α-trypsin inhibitor heavy chain H4, m/z 3272), were identified as putative biomarkers able to improve the detection of early stage ovarian cancer [36]. The gene discussed is TTR; the disease is ovarian carcinoma.