A decrease of Apo E in CSF of the SHR compared with WKY was found in the results here, but the proteins binding vitamin D, Apo A1, and α-1-macroglobulin are higher in the hypertensive group, which could explain the relationship between hypertension, inflammation, and amyloid pathology [11, 24]. The gene discussed is APOE; the disease is Hypertension.