Moreover, our group has previously described the putative role of CD8+ T subsets in controlling morbidity during human schistosomiasis, which was evidenced by the increased levels of activated HLA-DR+ CD8+ T lymphocytes in patients presenting intestinal clinical form (INT) of the disease and low levels of CD28+ CD8+ cells in hepatosplenic patients [51–53]. This evidence concerns the gene CD28 and schistosomiasis.