Syndrome of stagnation of liver Qi and spleen deficiency is one of the common syndromes of SHS and mental disorders in TCM clinic [18], our recently studies shown: the Xiaoyaosan (XYS) decoction reversed chronic stress induced decreases in brain-derived neurotrophic factor (BDNF) and increases in tyroxine hydroxylase (TrkB), and neurotrophin 3 (NT-3) in the frontal cortex and the hippocampal CA1 subregion [19]. The gene discussed is BDNF; the disease is mental disorder.