Our group performed a number of studies reporting that maternal serum angiogenic factors vascular endothelial growth factor receptor [VEGF-R1 (flt-1)], VEGF, angiopoetin (ANG-)1 and ANG-2 are potential markers of failed pregnancies—MA and EP, as their levels are significantly decreased in early pregnancy failure (MA or EP) at 6–8 weeks of gestation compared to those found in healthy intrauterine pregnancies [3, 23, 24]. Here, FLT1 is linked to microtia.