Increased plasma OPG concentrations are associated with coronary artery disease [6, 7] frequently accompanied by atherosclerosis, stroke, and vascular mortality [8, 9] as well as by subclinical atherosclerosis [10, 11] and overall cardiovascular morbidity and mortality [12] in obese nondiabetic subjects [13]. The gene discussed is TNFRSF11B; the disease is Stroke.