Avignon et al. investigated OPG concentrations and signs of myocardial ischemia perfusion on myocardial perfusion scintigraphy in patients with type 1 or 2 diabetes and concluded that OPG measurement can help to better define the diabetic population with an increased risk of developing SMI [51]. The gene discussed is TNFRSF11B; the disease is myocardial ischemia.